Determination of the Subcellular Origin of [14C] Acetylcholine (ACh) and [3H] Acetylpyrrolidinecholine (Apych) Released from Guinea-Pig Cerebral Cortex after Electrical Stimulation

6533b851fe1ef96bd12a96d7

RESEARCH PRODUCT

Determination of the Subcellular Origin of [14C] Acetylcholine (ACh) and [3H] Acetylpyrrolidinecholine (Apych) Released from Guinea-Pig Cerebral Cortex after Electrical Stimulation

subject

food and beverages Stimulation Compartment (chemistry)Synaptic vesicle Guinea pig chemistry.chemical_compound medicine.anatomical_structure chemistry In vivo Cerebral cortex medicine Biophysics Choline Neuroscience Acetylcholine medicine.drug

description

After in vivo application of radiolabelled choline, radioactive ACh is formed and can be released from the brain by electrical stimulation. However, its origin is still obscure because, due to the metabolical heterogeneity of synaptic vesicles, no subcellular compartment has been found with a specific activity (SA) corresponding to that of released transmitter. To bypass this heterogeneity problem, two different labelled precursors can be used.

year	journal	country	edition	language
1978-01-01

https://doi.org/10.1007/978-3-662-39532-5_216

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