6533b851fe1ef96bd12a98fe

RESEARCH PRODUCT

Antioxidant activity of cerium dioxide nanoparticles and nanorods in scavenging hydroxyl radicals

Ting WangTing WangFobang LiuFobang LiuYueshe WangUlrich PöschlHaijie TongAlexander FilippiSteven LelieveldTobias ReichJake WilsonWolfgang TremelKarsten Korschelt

subject

chemistry.chemical_classificationCerium oxideReactive oxygen speciesAntioxidantGeneral Chemical EngineeringRadicalmedicine.medical_treatmentNanoparticlechemistry.chemical_elementmacromolecular substances02 engineering and technologyGeneral Chemistry010402 general chemistry021001 nanoscience & nanotechnology01 natural sciences0104 chemical sciencesNanomaterialsCeriumchemistrymedicine0210 nano-technologyScavengingNuclear chemistry

description

Cerium oxide nanoparticles (CeNPs) have been shown to exhibit antioxidant capabilities, but their efficiency in scavenging reactive oxygen species (ROS) and the underlying mechanisms are not yet well understood. In this study, cerium dioxide nanoparticles (CeNPs) and nanorods (CeNRs) were found to exhibit much stronger scavenging activity than ·OH generation in phosphate buffered saline (PBS) and surrogate lung fluid (SLF). The larger surface area and higher defect density of CeNRs may lead to higher ·OH scavenging activity than for CeNPs. These insights are important to understand the redox activity of cerium nanomaterials and provide clues to the role of CeNPs in biological and environmental processes.

yearjournalcountryeditionlanguage
2019-01-24RSC Advances
https://doi.org/10.1039/c9ra00642g