6533b851fe1ef96bd12a990a
RESEARCH PRODUCT
Persistence of disease flares is associated with an inadequate colchicine dose in familial Mediterranean fever: A national multicenter longitudinal study.
Angela MiniaciNicolino RupertoMaria Greca MagnoliaAlessandra SpagnoloGiovanni ContiDavide MontinMaria CarrabbaLaura ObiciGiovanna FabioEdoardo MarraniGiovanna CapozioMarco CattaliniPatrizia BaroneMaddalena LancieriFrancesco CalzatiniValentina MoressaMaria Cristina MaggioGabriele SimoniniCamilla CelaniLuca CantariniFrancesca MazzaDiana SuteraRoberta MussinelliLuciana BredaMarta BustaffaRomina GallizziFrancesca OrlandoMaria AlessioAntonella InsalacoAlma Nunzia OlivieriDonato RiganteCarla GaggianoFrancesca RicciMarco Gattornosubject
Longitudinal studybusiness.industryFamilial Mediterranean feverInterleukinDiseaseFamilial Mediterranea fevermedicine.diseaseSymptom Flare UpColchicine; Humans; Interleukin 1 Receptor Antagonist Protein; Longitudinal Studies; Symptom Flare Up; Familial Mediterranean FeverPersistence (computer science)Familial Mediterranean Feverchemistry.chemical_compoundInterleukin 1 Receptor Antagonist ProteinSettore MED/38 - Pediatria Generale E SpecialisticachemistryColchicine Humans Interleukin 1 Receptor Antagonist Protein Longitudinal Studies Symptom Flare Up Familial Mediterranean FeverImmunologyCOLCHICINE RESISTANCEImmunology and AllergyMedicineColchicineHumansLongitudinal StudiesbusinessColchicinedescription
Familial Mediterranean fever (FMF) is characterized by self limited episodes of fever and polyserositis.1 MEFV gene en codes for a protein named Pyrin, which plays a pivotal role in the activation and secretion of IL-1.2 Daily colchicine is highly effective in preventing attacks in this disorder in a dose-related fashion.3 Many definitions of colchicine resistance are available in the literature. The European League Against Rheumatism (EULAR) guidelines defined resistance as one or more attacks per month in compliant patients who had been receiving the maxi mally tolerated dose for at least 6 months.4 A similar definition was confirmed by a recent consensus among experts.5 In the present national multicentric longitudinal study, we analyze the impact of colchicine treatment on disease activity and quality of life in real life in pediatric and adult patients with FMF.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 |