6533b851fe1ef96bd12a9947
RESEARCH PRODUCT
Acute intermittent nicotine treatment produces a reduction in the total number of FGF-2 immunoreactive astroglial cells in the substantia nigra of the rat: a stereological analysis.
Natale BelluardoGiuseppina LeoKjell FuxeJose A. AguirreLuigi F. AgnatiFang-ling Liusubject
Malemedicine.medical_specialtyNicotineCentral nervous systemFGF-2Substantia nigraStereologyFGF-1Cell CountBiologyFibroblast growth factornicotine; FGF-2; stereology; immunoreactivity; substantia nigra; FGF-1; FGF-5FGF-5NicotineRats Sprague-DawleyStereotaxic TechniquesInternal medicinemedicineAnimalsGeneral NeuroscienceAlkaloidImmunohistochemistryRatsSubstantia Nigramedicine.anatomical_structureEndocrinologyNicotinic agonistnervous systemsubstantia nigraAstrocytesStereotaxic techniquestereologyFibroblast Growth Factor 2immunoreactivitymedicine.drugnicotinedescription
To understand the morphological substrate of the nicotine effect on nigral FGF-2 expression, a stereological analysis of FGF-2 immunoreactive neuronal and glial profiles has been performed in the substantia nigra of the rat after acute intermittent nicotine treatment. The major finding of this paper is the demonstration that this type of nicotine treatment produces a significant reduction in the total number of nuclear FGF-2 immunoreactive astroglial profiles in the substantia nigra. A parallel analysis of nigral FGF-1 and FGF-5 immunoreactivities showed no effect of this type of nicotine treatment. The results may be explained by an inhibition of FGF-2 synthesis in a subpopulation of nigral astroglia by nicotinic receptor activation, favouring a reduction of astroglial neurotrophism in the substantia nigra.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-01-21 | Neuroscience letters |