6533b851fe1ef96bd12a99b0
RESEARCH PRODUCT
Origin of metazoan adhesion molecules and adhesion receptors as deduced from cDNA analyses in the marine sponge Geodia cydonium: a review.
Werner E. G. M�llersubject
HistologyDNA ComplementaryMembrane GlycoproteinsbiologyCell adhesion moleculeProtistMembrane ProteinsCell Biologybiology.organism_classificationmedicine.disease_causeReceptor tyrosine kinasePathology and Forensic MedicineCell biologyPoriferaSuberites domunculaSpongeBiochemistryPlatelet Glycoprotein GPIb-IX Complexbiology.proteinmedicineAnimalsSignal transductionReceptorCell Adhesion MoleculesGalectindescription
The phylogenetic relationships of the kingdom Animalia (Metazoa) have long been questioned. Whether the lowest eukaryotic multicellular organisms, the metazoan phylum Porifera (sponges), independently evolved multicellularity from a separate protist lineage (polyphyly of animals) or whether they were derived from the same protist group as the other animal phyla (monophyly) remains unclear. Analyses of the genes that are typical for multicellularity, e.g. those coding for adhesion molecules (galectin) and adhesion receptors (receptor tyrosine kinase, integrin receptor, receptors featuring scavenger receptor cysteine-rich domains) or elements involved in signal transduction pathways (G-proteins, Ser/Thr protein kinases), especially from the marine sponge Geodia cydonium, indicate that all animals, including sponges, are of monophyletic origin.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-09-01 | Cell and tissue research |