6533b851fe1ef96bd12aa033
RESEARCH PRODUCT
Phenylalanine Hydroxylase Participation in the Synthesis of Serotonin and Pteridines in Drosophila melanogaster
Salvador AlcañizFrancisco J. Silvasubject
PharmacologyPhenylalanine hydroxylasebiologyTyrosine hydroxylaseImmunologyTryptophanTryptophan hydroxylaseHydroxylationchemistry.chemical_compoundchemistryBiochemistrybiology.proteinAromatic amino acidsSerotonin5-Hydroxytryptophandescription
Abstract Phenylalanine hydroxylase is involved in the synthesis of serotonin and pteridines, probably catalysing the hydroxylation of tryptophan and a tetrahydropterin oxidase reaction, respectively. Supplementation of the wild-type Drosophila diet with either L-Phe or L-Trp induced a significant increase in the phenylalanine hydroxylase concentration, while L-Tyr supplementation had no effect. The level of serotonin in adult heads of the PAH-defective mutant Henna recessive-3 was significantly lower than that obtained for the wild-type strain. A 4-fold increase in the concentration of phenylalanine hydroxylase is observed during the pharate adult head development. It occurs in parallel with the synthesis of red pigments in the eye.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-03-01 | Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology |