Acid-mediated reaction of bis(pyridine)iodonium(I) tetrafluoroborate with aromatic compounds. A selective and general iodination method

6533b851fe1ef96bd12aa1a0

RESEARCH PRODUCT

Acid-mediated reaction of bis(pyridine)iodonium(I) tetrafluoroborate with aromatic compounds. A selective and general iodination method

Miguel A. García-martín José M. González José Barluenga Gregorio Asensio Gregorio Asensio Gregorio Asensio Pedro J. Campos

subject

Acid catalysis chemistry.chemical_compound Electrophilic substitution Tetrafluoroborate chemistry Organic Chemistry Pyridine Regioselectivity Halogenation Organic chemistry Bis(pyridine)iodonium(I) tetrafluoroborate Chemical society

description

Reaction of aromatic compounds with bis(pyridine)iodonium(I) tetrafluoroborate (IPy2BF4) in the presence of HBF4 or CF3SO3H in CH2Cl2 at room temperature furnishes monoiodo derivatives with excellent regioselectivity and yields. Use of either acid gives comparable results with activated aromatics, whereas CF3SO3H is much more effective in the iodination of deactivated aromatics. © 1993 American Chemical Society.

year	journal	country	edition	language
1993-04-01	The Journal of Organic Chemistry

https://doi.org/10.1021/jo00060a020

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