6533b851fe1ef96bd12aa215

RESEARCH PRODUCT

The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus.

Santiago F. ElenaRafael SanjuánAndrés Moya

subject

PopulationMutantMutagenesis (molecular biology technique)Evolutionary biologyVesicular stomatitis Indiana virusSingle-nucleotide substitutionsGenetic variationAnimalsPoint MutationMutational fitness effectseducationGeneticseducation.field_of_studyMultidisciplinarybiologyPoint mutationRNAGenetic VariationRNA virusRNA viral genomesBiological Sciencesbiology.organism_classificationBiological EvolutionGenetics PopulationVesicular stomatitis virusMutagenesis Site-Directed

description

6 pages, 3 figures.-- PMID: 15159545 [PubMed].-- PMCID: PMC420405.-- Supporting information (Table 3: Relevant information about each single-nucleotide substation mutant created) available at: http://www.pnas.org/content/101/22/8396/suppl/DC1

yearjournalcountryeditionlanguage
2004-05-24Proceedings of the National Academy of Sciences of the United States of America
10.1073/pnas.0400146101https://pubmed.ncbi.nlm.nih.gov/15159545