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RESEARCH PRODUCT
The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols
Andreas DaiberNing XiaAndy W C ManHuige Lisubject
0301 basic medicineCircadian clock610 MedizinReview ArticleGut floraHealth benefitsBioinformaticsThemed Section: Review Articles03 medical and health sciences0302 clinical medicineNutraceutical610 Medical sciencesMedicineCircadian rhythmPharmacologybiologybusiness.industryPolyphenolsfood and beveragesbiology.organism_classificationCircadian RhythmDietGastrointestinal Microbiome030104 developmental biologyPolyphenolDietary Supplementsbusiness030217 neurology & neurosurgerydescription
Polyphenols are secondary metabolites of plants that have been widely studied for their health benefits as antioxidants. In the last decade, several clinical trials and epidemiological studies have shown that long-term consumption of polyphenol-rich diet protects against chronic diseases such as cancers and cardiovascular diseases. Current cardiovascular studies have also suggested an important role of gut microbiota and circadian rhythm in the pathogenesis metabolic and cardiovascular diseases. It is known that polyphenols can modulate the composition of core gut microbiota and interact with circadian clocks. In this article, we summarize recent findings, review the molecular mechanisms and the potential of polyphenols as dietary supplements for regulating gut microbiota and circadian rhythms, and discuss future research directions. LINKED ARTICLES: This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-06-01 | British Journal of Pharmacology |