6533b851fe1ef96bd12aa29f

RESEARCH PRODUCT

Antibody persistence and immune memory elicited by combined hepatitis A and B vaccination in older adults.

Gudrun Groeger-bicanicBernard HoetMichel StoffelThomas Höhler

subject

MaleTwinrixHepatitis A AntibodiesCohort StudiesMedicineHumansHepatitis B VaccinesProspective StudiesVaccines CombinedHepatitis B AntibodiesProspective cohort studyAgedHepatitis A VaccinesHepatitis B Surface AntigensGeneral VeterinaryGeneral Immunology and Microbiologybiologybusiness.industryPublic Health Environmental and Occupational Healthvirus diseasesHepatitis AMiddle Agedmedicine.diseaseVirologydigestive system diseasesVaccinationClinical trialInfectious DiseasesImmunologyAntibody Formationbiology.proteinMolecular MedicineFemaleViral diseaseAntibodybusinessImmunologic MemoryCohort study

description

Response to hepatitis A and B vaccines has been reported to decline with age. This open, prospective, single-site study examined the long-term response to the combined hepatitis A/B vaccine Twinrix in 98 primary responders aged 45-67 years. Levels of antibody against hepatitis A virus (HAV) and hepatitis B surface antigen (HBs) were tested 30 months after initial vaccination. At this stage, all participants remained seropositive for anti-HAV and 70% for anti-HBs. A booster vaccination was offered to those who had responded to the first vaccination but then lost protective levels of anti-HBs. An anamnestic response was observed in all cases.

yearjournalcountryeditionlanguage
2007-02-01Vaccine
10.1016/j.vaccine.2006.10.024https://pubmed.ncbi.nlm.nih.gov/17097774