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RESEARCH PRODUCT
Novel hydrogels based on a polyasparthydrazide. Synthesis and characterization
Pier Luigi San BiagioDonatella BuloneGaetano GiammonaBianca CarlisiGiovanna PitarresiGennara Cavallarosubject
Polymers and Plasticsmedicine.diagnostic_testChemistryOrganic ChemistryCondensed Matter PhysicsLight scatteringSpectrophotometryParticle-size distributionPolymer chemistrySelf-healing hydrogelsMaterials ChemistrymedicineChemical stabilityPhysical and Theoretical ChemistrySwellingmedicine.symptomGlass transitionThermal analysisdescription
α,β-polyasparthydrazide (PAHy), a synthetic water-soluble biocompatible polymer, was chemically crosslinked with ethyleneglycol diglycidylether (EGDGE), in order to obtain water swellable microparticies. These were characterized by means of FT-IR spectrophotometry and by means of particle size distribution analysis. The mean pore size of the prepared gels as various crosslinking ratios and the fractal dimensions were determined by light scattering measurements. Swelling measurements gave evidence of the high affinity of PAHy-EGDGE microparticles towards aqueous media at different pH values. The physical state of the prepared networks was evaluated by means of X-rays diffractometry and thermal analysis. A peculiar effect of the degree of cross-linking on the glass transition temperature (T g ) value was shown. In vitro chemical and enzymatic stability studies suggested that the prepared samples do not undergo any degradation alter treatment at pH 1. 7.4 and 10 as well as after incubation with enzymes such as peptin and α-chymotrypsin.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-11-01 | Macromolecular Chemistry and Physics |