6533b852fe1ef96bd12aa38c
RESEARCH PRODUCT
Visceral Adiposity Index
Angela CriscimannaSalvatore VitabileMassimo MidiriMassino GaliaCarla GiordanoAldo GalluzzoMarco Calogero Amatosubject
AdultMaleCardiovascular and Metabolic Riskmedicine.medical_specialtyWaistEndocrinology Diabetes and MetabolismAdipose tissueIntra-Abdominal FatLogistic regressionBody Mass IndexYoung Adultchemistry.chemical_compoundRisk FactorsInternal medicineDiabetes mellitusInternal MedicinemedicineHumansTriglyceridesOriginal ResearchAgedAged 80 and overAdvanced and Specialized Nursingbusiness.industryCholesterolCholesterol HDLMiddle Agedmedicine.diseaseLogistic ModelsEndocrinologychemistryCardiovascular DiseasesCardiologyFemaleWaist CircumferenceMetabolic syndromebusinessBody mass indexLipid Accumulation Productdescription
OBJECTIVE To individuate a novel sex-specific index, based on waist circumference, BMI, triglycerides, and HDL cholesterol, indirectly expressing visceral fat function. RESEARCH DESIGN AND METHODS Visceral adiposity index (VAI) was first modeled on 315 nonobese healthy subjects. Using two multiple logistic regression models, VAI was retrospectively validated in 1,498 primary care patients in comparison to classical cardio- and cerebrovascular risk factors. RESULTS All components of metabolic syndrome increased significantly across VAI quintiles. VAI was independently associated with both cardiovascular (odd ratio [OR] 2.45; 95% CI 1.52–3.95; P < 0.001) and cerebrovascular (1.63; 1.06–2.50; P = 0.025) events. VAI also showed significant inverse correlation with insulin sensitivity during euglycemic-hyperinsulinemic clamp in a subgroup of patients (Rs = −0.721; P < 0.001). By contrast, no correlations were found for waist circumference and BMI. CONCLUSIONS Our study suggests VAI is a valuable indicator of “visceral adipose function” and insulin sensitivity, and its increase is strongly associated with cardiometabolic risk.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-01-12 | Diabetes Care |