6533b852fe1ef96bd12aa42e

RESEARCH PRODUCT

Multiple granular cell tumors with metachronous occurrence in tongue and vulva. Clinicopathological and immunohistochemical study

Francisco Vera-sempereBeatriz Vera-sireraPablo ZabalaCarlos Aviño-mira

subject

Granular cell tumorPathologymedicine.medical_specialtybiologyPseudoepitheliomatous HyperplasiaCase ReportVimentinEndoglinmedicine.diseaseMultiple granular cell tumorsPathology and Forensic MedicineVulvamedicine.anatomical_structureOtorhinolaryngologyStromatongueTonguemedicinebiology.proteinImmunohistochemistryGeneral Dentistrypseudoepitheliomatous hyperplasia

description

Granular cell tumor (GCT) usually occurs as a single tumor, although sometimes multiple lesions can occur. In present report we analyze the clinicopathological and immunohistochemical features of a multiple GCT involving the tongue of a 14-year-old girl, with no other abnormalities, with a metachronous occurrence of a second GCT in vulva, after a period of 10 years. Both tumors revealed S-100, vimentin and CD57 positivity. In addition, over expression of calretinin was observed in tumor cells located in the vicinity of pseudoepitheliomatous hyperplasia (PEH) of the tongue. Tumor vasculature situated close to the PEH showed marked CD105 reactivity, data not described so far, suggesting an interaction between PEH cells and underlying stroma, since GCT completely lacks CD105 vessels. Our study emphasizes that patients with GCT, especially young patients, should be followed long-term, looking for multiple tumors or other abnormalities suggestive of a systemic syndrome, given the associations described in multiple GCT.

yearjournalcountryeditionlanguage
2014-01-01Journal of Oral and Maxillofacial Pathology
https://doi.org/10.4103/0973-029x.151343