Reactivity of asymmetric benzo-condensed diazines with nitrilimine dipoles in the 1,3-dipolar cycloaddition reactions

6533b852fe1ef96bd12aa4ca

RESEARCH PRODUCT

Reactivity of asymmetric benzo-condensed diazines with nitrilimine dipoles in the 1,3-dipolar cycloaddition reactions

Anna Maria Almerico Annalisa Guarcello Antonino Lauria Gaetano Dattolo Gabriella Macaluso

subject

nitrilimine dipole Chemistry Nitrilimine 1 3-dipolar cycloaddition reaction Organic Chemistry diazine Settore CHIM/06 - Chimica Organica diastereoselectivity Photochemistry Settore CHIM/08 - Chimica Farmaceutica Biochemistry Cycloaddition chemistry.chemical_compound Dipole Quinoxaline Computational chemistry Drug Discovery 1 3-Dipolar cycloaddition Quinazoline Reactivity (chemistry)

description

The reactivity of asymmetric benzo-condensed diazines in the 1,3-dipolar cycloaddition reactions with nitrilimines was investigated. The results demonstrated that, at variance with the symmetric quinoxaline, a certain grade of diastereoselectivity emerged. Moreover in the case of the 5-methylquinoxaline and quinazoline a mono-cycloadduct was obtained.

year	journal	country	edition	language
2009-12-01	Tetrahedron Letters

https://doi.org/10.1016/j.tetlet.2009.10.062

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