6533b852fe1ef96bd12aa4f7
RESEARCH PRODUCT
T-T cell interactions during in vitro cytotoxic T lymphocyte responses. III. Antigen-specific T helper cells release nonspecific mediator(s) able to help induction of H-2-restricted cytotoxic T lymphocyte responses across cell-impermeable membranes.
Rosemarie DelzeitMartin RöllinghoffKlaus PfizenmaierHermann Wagnersubject
Cytotoxicity ImmunologicIsoantigensCell Membrane PermeabilityT cellT-LymphocytesImmunologyCellLymphocyte CooperationStreptamerBiologyInterleukin 21EpitopesMicemedicineImmunology and AllergyCytotoxic T cellAnimalsAntigen-presenting cellMice Inbred BALB CH-2 AntigensT helper cellCell biologyParainfluenza Virus 1 HumanMice Inbred C57BLCTL*medicine.anatomical_structureSolubilityTrinitrobenzenesMice Inbred CBAdescription
T helper cell induction and the specificity of T cell-mediated help as generated during alloreactive and H-2-restricted, virus- or hapten-specific cytotoxic T lymphocyte (CTL) responses have been compared. With the use of a double-chamber culture system, it was possible to dissect and separately analyze the induction phase of T helper cells from the T helper cell effector function. The data obtained revealed that during alloreactive as well as H-2-restricted T cell responses, antigen-specific T helper cells are induced. Upon specific restimulation of T helper cells, helper cell function is mediated across a cell-impermeable membrane via soluble products in an apparently nonspecific and nonrestricted manner. The data suggest that similar rules govern T-T cell interactions in alloreactive and H-2-restricted CTL responses.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1980-08-01 | European journal of immunology |