6533b852fe1ef96bd12aaa71
RESEARCH PRODUCT
A Nanoparticulate Drug-Delivery System for Rivastigmine: Physico-Chemical and in vitro Biological Characterization
Gaetano GiammonaGiovanna PitarresiMaria Pia CasalettoMariano LicciardiEmanuela Fabiola CraparoMaria Luisa Bondìsubject
Aqueous solutionPolymers and PlasticsChemistryNanoparticleChemical modificationBioengineeringBiomaterialschemistry.chemical_compoundChemical engineeringDrug deliveryMaterials ChemistryCopolymerOrganic chemistryMicroemulsionDrug carrierTriacetinBiotechnologydescription
The preparation and characterization of surface-PEGylated polymeric nanoparticles are described. These systems were obtained by UV irradiation of PHM and PHM-PEG 2000 as an inverse microemulsion, using an aqueous solution of the PHM/PHM-PEG 2000 copolymer mixture as the internal phase and triacetin saturated with water as the external phase, and characterized by dimensional analysis, zeta-potential measurements and XPS. in vitro biological tests demonstrated their cell compatibility and their ability to escape from phagocytosis. Rivastigmine was encapsulated into the nanoparticle structure and drug-release profiles from loaded samples were investigated in PBS at pH = 7.4 and human plasma.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-11-27 | Macromolecular Bioscience |