6533b852fe1ef96bd12aac6c
RESEARCH PRODUCT
The value of intraoperative frozen section examination of sentinel lymph nodes in surgical management of breast carcinoma.
Salvatore VieniDaniela CabibiSalvatore FricanoCalogero CipollaIrene GentileMario Adelfio Latterisubject
Adultmedicine.medical_specialtyBreast surgerymedicine.medical_treatmentSentinel lymph nodeBreast NeoplasmsSettore MED/08 - Anatomia PatologicaSensitivity and SpecificityIntraoperative PeriodBreast cancermedicineFrozen SectionsHumansBreastSentinel lymph node - Frozen section - Intraoperative - Breast carcinomaLymph nodeMastectomyAgedNeoplasm StagingRetrospective StudiesAged 80 and overbusiness.industrySentinel Lymph Node BiopsyGeneral surgeryCarcinoma Ductal BreastAxillary Lymph Node DissectionReproducibility of ResultsMiddle Agedmedicine.diseaseCarcinoma LobularSettore MED/18 - Chirurgia Generalemedicine.anatomical_structureLymphatic MetastasisAxillaLymph Node ExcisionSurgeryFemaleIntraoperative PeriodRadiologyLymph NodesbusinessBreast carcinomaMastectomydescription
PURPOSE: In breast cancer staging, the need for intraoperative sentinel lymph node (SLN) evaluation has still not been adequately established. This study investigates the impact of intraoperative frozen section (FS) evaluation of SLN to avoid subsequent axillary lymph node dissection (ALND) in patients with positive SLN. METHODS: A retrospective review of 364 breast cancer patients undergoing SLN biopsy with intraoperative FS evaluation of SLN was performed. RESULTS: Sensitivity and accuracy of FS examination of SLN were 76.4% and 94.2%, respectively. The sensitivity was significantly higher in larger tumors (p < 0.01). No significant correlation was found between FS and histologic type. A second intervention was avoided in 83.9% of the patients with positive SLN. CONCLUSIONS: Intraoperative FS examination of the SLN is a useful predictor of axillary lymph node status in breast cancer patients. The majority of SLN-positive patients allows for immediate ALND in a one-stage surgical procedure.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-07-13 |