Selective adsorption of oppositely charged PNIPAAM on halloysite surfaces: a route to thermo-responsive nanocarriers.

6533b852fe1ef96bd12aaeed

RESEARCH PRODUCT

Selective adsorption of oppositely charged PNIPAAM on halloysite surfaces: a route to thermo-responsive nanocarriers.

Filippo Parisi Giuseppe Lazzara Lorenzo Lisuzzo Giuseppe Cavallaro Stefana Milioto

subject

Amide Materials science Technological application Bioengineering 02 engineering and technology engineering.material 010402 general chemistry 01 natural sciences Halloysite Lower critical solution temperature Acrylic monomer chemistry.chemical_compound Adsorption thermo-responsive material Kaolinite General Materials Science Electrical and Electronic Engineering Non-steroidal anti-inflammatory drug Poly (n isopropylacrylamide)Hybrid material Targeted drug delivery Thermodynamic behaviors Controlled drug delivery Mechanical Engineering Halloysite General Chemistry 021001 nanoscience & nanotechnology Controlled release 0104 chemical sciences Nanotube Hydrogel Chemical engineering chemistry Mechanics of Materials Selective adsorption Self-healing hydrogels engineering Poly(N-isopropylacrylamide)0210 nano-technology Hybrid material Temperature-responsive controlled release Yarn Controlled release Thermo-responsive

description

Halloysite nanotubes were functionalized with stimuli-responsive macromolecules to generate smart nanohybrids. Poly(N-isopropylacrylamide)-co-methacrylic acid (PNIPAAM-co-MA) was selectively adsorbed into halloysite lumen by exploiting electrostatic interactions. Amine-terminated PNIPAAM polymer was also investigated that selectively interacts with the outer surface of the nanotubes. The adsorption site has a profound effect on the thermodynamic behavior and therefore temperature responsive features of the hybrid material. The drug release kinetics was investigated by using diclofenac as a non-steroidal anti-inflammatory drug model. The release kinetics depends on the nanoarchitecture of the PNIPAAM/halloysite based material. In particular, diclofenac release was slowed down above the LCST for PNIPAAM-co-MA/halloysite. Opposite trends occurred for halloysite functionalized with PNIPAAM at the outer surface. This work represents a further step toward the opportunity to extend and control the delivery conditions of active species, which represent a key point in technological applications. © 2018 IOP Publishing Ltd.

year	journal	country	edition	language
2018-05-18	Nanotechnology

10.1088/1361-6528/aac5c3 https://pubmed.ncbi.nlm.nih.gov/29771681