6533b852fe1ef96bd12ab585

RESEARCH PRODUCT

Verapamil Inhibits the Respiration Rate of Cancer Cells

Wolfgang Mueller-klieserPeter Vaupel

subject

Drugbusiness.industrymedia_common.quotation_subjectchemistry.chemical_elementPharmacologyCalciumIn vitroEhrlich ascites carcinomachemistryCancer cellcardiovascular systemmedicineVerapamilEffluxCytotoxicitybusinessmedia_commonmedicine.drug

description

Calcium antagonists have successfully been used in the treatment of hypertension, cardiac arrhythmias and coronary heart disease. Recent evidence has suggested that such agents may also play a role in the treatment of malignant tumors. Verapamil, a calcium entry blocker, has been reported to enhance the cytotoxicity of several anticancer drugs under in vitro- and in vivo-conditions [1–10]. The effects observed could be explained by an enhanced drug accumulation due to a Verapamil-induced inhibition of the drug efflux from the cancer cells.

yearjournalcountryeditionlanguage
1986-01-01
https://doi.org/10.1007/978-1-4684-5188-7_77