Synthesis of sialyl-Tn antigen. Regioselective sialylation of a galactosamine threonine conjugate unblocked in the carbohydrate portion

6533b852fe1ef96bd12ab5de

RESEARCH PRODUCT

Synthesis of sialyl-Tn antigen. Regioselective sialylation of a galactosamine threonine conjugate unblocked in the carbohydrate portion

subject

Sialyl Tn antigen Stereochemistry Organic Chemistry Regioselectivity Carbohydrate Biochemistry carbohydrates (lipids)chemistry.chemical_compound Biochemistry chemistry Antigen Galactosamine Drug Discovery Threonine Conjugate

description

Abstract Regioselective and stereocontrolled formation of the sialyl-Tn antigen conjugate 6 was achieved by reacting the NeuNAc-2-xanthate 2 with the GalNAc threonine acceptor 5 bearing three hydroxy groups. Complete deprotection afforded the sialyl-Tn antigen structure 11 .

year	journal	country	edition	language
1994-11-01	Tetrahedron Letters

https://doi.org/10.1016/s0040-4039(00)78495-4

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