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RESEARCH PRODUCT

Subclinical atherosclerosis and fetuin-A plasma levels in essential hypertensive patients

Francesco VaccaroSantina CottoneGiuseppe MulèFrancesca IncalcaterraRosalia ArsenaClelia LunaCalogero GeraciMarco GuarneriGiovanni Cerasola

subject

MaleSettore MED/09 - Medicina Internaalpha-2-HS-GlycoproteinPhysiologyDinoprostKidneyEssential hypertensionmedicine.disease_causeCarotid Intima-Media ThicknessGastroenterologyatherosclerosiRisk FactorsMedicinebiologyArea under the curveMiddle Agedmusculoskeletal systemHypertensioncardiovascular systemRegression AnalysisBiomarker (medicine)FemaleEssential HypertensionCardiology and Cardiovascular MedicineAdultmedicine.medical_specialtyRenal functionPredictive Value of TestsInternal medicineInternal MedicineHumanscardiovascular diseasesintima-media thicknessInterleukin 6Settore MED/14 - NefrologiaInterleukin-6Tumor Necrosis Factor-alphabusiness.industrySurrogate endpointAtherosclerosismedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareFetuinfetuin-AOxidative StressCross-Sectional StudiesEndocrinologyinflammationCase-Control Studiesbiology.proteinbusinessBiomarkersOxidative stress

description

The intima-media thickness (IMT) is considered as a surrogate marker for atherosclerotic disease. The aim of this study was to analyze the relationship of carotid IMT with fetuin-A in patients with essential hypertension (EH) and normal renal function. The plasma levels of fetuin-A, interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and the biomarker of oxidative stress 8-iso-PGF2alpha were assayed in samples from 105 untreated EH patients. Carotid IMT measurements were also performed. EH was studied overall and after dividing in EH with IMT ≥ and 0.9 mm (AUC (area under the curve) 0.738, P<0.0001). Our results suggest that in EH, fetuin-A is associated with the IMT independently of oxidative stress and renal function, thus predicting increases in the IMT.

yearjournalcountryeditionlanguage
2012-09-14Hypertension Research
https://doi.org/10.1038/hr.2012.136