6533b852fe1ef96bd12ab80c

RESEARCH PRODUCT

Non-Small Cell Lung Cancer Harboring Concurrent EGFR Genomic Alterations: A Systematic Review and Critical Appraisal of the Double Dilemma

Martina GrecoValentina CalòSergio RizzoAlessandro PerezF. IaconoSara IngugliaStefania CusenzaGianni PantusoDelia SardoL. InsalacoLorena IncorvaiaMarta CastigliaMarco BonoValerio GristinaAntonio GalvanoMaria La MantiaKatia CalcaraAntonio RussoGiulia SantanelliMaria Chiara LisantiL. CastellanaSofia CutaiaNadia BarracoV. Bazan

subject

0301 basic medicineEGFRNSCLC03 medical and health sciences0302 clinical medicinesystematic reviewPathologyRB1-214MedicineEpidermal growth factor receptorLung cancerPathologicalbiologybusiness.industrymedicine.diseaserespiratory tract diseasesconcurrent genomic alterationCritical appraisal030104 developmental biologyLung cancer cellconcurrent genomic alterationsNGS030220 oncology & carcinogenesisConcomitantCancer researchbiology.proteinNon small cellbusinessTyrosine kinase<i>EGFR</i>

description

The molecular pathways which promote lung cancer cell features have been broadly explored, leading to significant improvement in prognostic and diagnostic strategies. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have dramatically altered the treatment approach for patients with metastatic non-small cell lung cancer (NSCLC). Latest investigations by using next-generation sequencing (NGS) have shown that other oncogenic driver mutations, believed mutually exclusive for decades, could coexist in EGFR-mutated NSCLC patients. However, the exact clinical and pathological role of concomitant genomic aberrations needs to be investigated. In this systematic review, we aimed to summarize the recent data on the oncogenic role of concurrent genomic alterations, by specifically evaluating the characteristics, the pathological significance, and their potential impact on the treatment approach.

yearjournalcountryeditionlanguage
2021-06-01Journal of Molecular Pathology
https://doi.org/10.3390/jmp2020016