6533b852fe1ef96bd12ab86d

RESEARCH PRODUCT

Nephrotoxicity in the setting of invasive fungal diseases

Andrew J. Ullmann

subject

Antifungalmedicine.medical_specialtyAntifungal Agentsmedicine.drug_classTreatment outcomeLength of hospitalizationContext (language use)DermatologyNephrotoxicityImmunocompromised HostAmphotericin BAmphotericin BmedicineHumansIn patientIntensive care medicineAdverse effectbusiness.industryGeneral MedicineLength of StayTreatment OutcomeInfectious DiseasesMycosesKidney Diseasesbusinessmedicine.drug

description

Amphotericin B, a broad spectrum antifungal agent, is widely used despite significant adverse events including nephrotoxicity. Nephrotoxicity occurs frequently in patients receiving amphotericin B. Different definitions for nephrotoxicity are reviewed in the context of outcome in patients with invasive fungal diseases. In most publications, mortality was higher in patients experiencing nephrotoxicity and mean hospital length of stay was prolonged. As a consequence, the use of less nephrotoxic antifungal agents could improve treatment outcomes.

yearjournalcountryeditionlanguage
2008-07-01Mycoses
https://doi.org/10.1111/j.1439-0507.2008.01525.x