6533b852fe1ef96bd12ab926
RESEARCH PRODUCT
Chronic brain damage in HIV-infected individuals under antiretroviral therapy is associated with viral reservoirs, sulfatide release, and compromised cell-to-cell communication
Daniela D’amicoRosario BaroneValentina Di FeliceBeau AncesBrendan PrideauxEliseo A. Eugeninsubject
Mass spectrometry imagingPharmacologyCellular and Molecular NeuroscienceReservoirsGap junctionWhite matterMolecular MedicineCell BiologyHANDCalcium waveMolecular Biologydescription
HIV infection has become a chronic and manageable disease due to the effective use of antiretroviral therapies (ART); however, several chronic aging-related comorbidities, including cognitive impairment, remain a major public health issue. However, these mechanisms are unknown. Here, we identified that glial and myeloid viral reservoirs are associated with local myelin damage and the release of several myelin components, including the lipid sulfatide. Soluble sulfatide compromised gap junctional communication and calcium wave coordination, essential for proper cognition. We propose that soluble sulfatide could be a potential biomarker and contributor to white matter compromise observed in HIV-infected individuals even in the current ART era.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2023-04-01 | Cellular and Molecular Life Sciences |