6533b853fe1ef96bd12ac0ff

RESEARCH PRODUCT

“Masked” Philadelphia chromosome resulting from a t(X;22) in chronic myeloid leukemia

G. GranataGiusi BarbataA. SantoroM.c. GiglioP. Carbone

subject

MaleCancer Researchmedicine.medical_specialtyX ChromosomeChromosomes Human Pair 22Chromosomal translocationBiologyPhiladelphia chromosomeTranslocation Genetichemic and lymphatic diseasesGeneticsmedicineHumansPhiladelphia ChromosomeMolecular BiologyBone marrow cellX chromosomeGeneticsCytogeneticsMyeloid leukemiaChromosomeMiddle Agedmedicine.diseaseMolecular biologyLeukemia MyeloidKaryotyping

description

Abstract A rare cytogenetic finding in chronic myeloid leukemia is reported. It consisted in a “masked” Philadelphia chromosome, resulting from an unusual translocation between chromosomes #22 and X. The t(X;22) was present in 100% of direct and cultured bone marrow cell preparations. Chromosome #9 did not seem to be involved in the formation of the Ph marker. Involvement of the X chromosome in karyotypic changes of hematologic diseases, with particular respect to chronic myeloid leukemia, is discussed.

yearjournalcountryeditionlanguage
1988-02-01Cancer Genetics and Cytogenetics
https://doi.org/10.1016/0165-4608(88)90204-x