6533b853fe1ef96bd12ac23c
RESEARCH PRODUCT
A short and modular approach towards 3,5-disubstituted indolizidine alkaloids.
Till OpatzSina ZinnMarco M. Nebesubject
IndolizidinesIndolizidinesMolecular Structure010405 organic chemistryChemistryStereochemistryOrganic ChemistryIndolizidine010402 general chemistry01 natural sciencesBiochemistryReductive amination0104 chemical scienceschemistry.chemical_compoundAlkaloidsMoleculeEpimerPhysical and Theoretical ChemistrySequence (medicine)description
3,5-Dialkyl indolizidines have been prepared in four linear steps from commercially available starting materials. The sequence involves two direct α-functionalization steps and a subsequent reductive amination and provides diastereoselective access to both C-3 epimers of the 5,9-trans-substituted indolizines. The naturally occurring indolizidines 195B and 223AB have been synthesized using this methodology.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-07-06 | Organicbiomolecular chemistry |