6533b853fe1ef96bd12ac2f2

RESEARCH PRODUCT

Nitric Oxide-Scavenging Properties of Some Chalcone Derivatives

Felipe HerenciaM.pilar Lo´pez-garcı́aAmalia UbedaM.luisa Ferrándiz

subject

Cancer ResearchChalconePhysiologyStereochemistryChemistryClinical BiochemistryFree Radical ScavengersNitric OxideBiochemistryScavengerNitric oxidechemistry.chemical_compoundChalconeReaction rate constantSpermine NONOateOxyhemoglobinsOxidation-ReductionScavengingMethemoglobin

description

Abstract The implication of NO in many inflammatory diseases has been well documented. We have previously reported that some chalcone derivatives can control the iNOS pathway in inflammatory processes. In the present study, we have assessed the NO-scavenging capacity of three chalcone derivatives (CH8, CH11, and CH12) in a competitive assay with HbO2, a well-known physiologically relevant NO scavenger. Our data identify these chalcones as new NO scavengers. The estimated second-order rate constants (ks) for the reaction of the three derivatives with NO is in the same range as the value obtained for HbO2, with CH11 exerting the greatest effect. These results suggest an additional action of these compounds on NO regulation.

yearjournalcountryeditionlanguage
2002-03-14Nitric Oxide
https://doi.org/10.1006/niox.2001.0396