The effect of pH on polymorph formation of the pharmaceutically active compound tianeptine.

6533b853fe1ef96bd12ac39d

RESEARCH PRODUCT

The effect of pH on polymorph formation of the pharmaceutically active compound tianeptine.

Liana Orola Mikelis V. Veidis Aleksandrs Platonenko Sergey Belyakov Andris Actins Inese Sarcevica

subject

chemistry.chemical_classification Hydrogen bond Chemistry Thiazepines Carboxylic acid Pharmaceutical Science Crystal structure Antidepressive Agents Tricyclic Hydrogen-Ion Concentration law.invention Amorphous solid Crystallography chemistry.chemical_compound X-Ray Diffraction law Active compound Zwitterion Spectroscopy Fourier Transform Infrared medicine Tianeptine Crystallization Crystallization Powder Diffraction medicine.drug

description

The anti-depressant pharmaceutical tianeptine has been investigated to determine the dynamics of polymorph formation under various pH conditions. By varying the pH two crystalline polymorphs were isolated. The molecular and crystal structures have been determined to identify the two polymorphs. One polymorph is an amino carboxylic acid and the other polymorph is a zwitterion. In the solid state the tianeptine moieties are bonded through hydrogen bonds. The zwitterion was found to be less stable and transformed to the acid form. During this investigation an amorphous form was identified.

year	journal	country	edition	language
2012-02-16	International journal of pharmaceutics

10.1016/j.ijpharm.2012.04.061 https://pubmed.ncbi.nlm.nih.gov/22569228

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