6533b853fe1ef96bd12ac3cf

RESEARCH PRODUCT

Soluble CD40L and Cardiovascular Risk in Asymptomatic Low-Grade Carotid Stenosis

Salvatore NovoBasili SRosalba TantilloFalco AValentina Davi'Novo GiuseppinaEgle CorradoCarlo Maria BarbagalloDavi G.

subject

MaleRiskmedicine.medical_specialtySoluble CD40LCD40 LigandAsymptomaticatherosclerosiPredictive Value of TestsInternal medicineHumansrisk factorsMedicineRisk factorStrokeProportional Hazards ModelsAdvanced and Specialized NursingbiologyInterleukin-6business.industryProportional hazards modelVascular diseaseC-reactive proteinMiddle Agedmedicine.diseaseSurgeryStrokecarotid stenosiStenosisC-Reactive ProteinSolubilityinflammationPredictive value of testsbiology.proteinCardiologycarotid stenosisFemaleNeurology (clinical)atherosclerosismedicine.symptomatherosclerosis; carotid stenosis; inflammation; risk factorsCardiology and Cardiovascular MedicinebusinessFollow-Up Studies

description

Background and Purpose— We investigated whether soluble CD40L (sCD40L) may predict the risk of cardiovascular (CV) events in patients with asymptomatic carotid plaques. Methods— Forty-two patients with asymptomatic low-grade carotid stenosis (ALCS) and 21 controls without any carotid stenosis were enrolled. All subjects had at least a major cardiovascular risk factor (CRF). Plasma levels of C-reactive protein (CRP), IL-6, and sCD40L were measured. Subjects were reviewed every 12 months (median follow-up, 8 years). Results— ALCS patients had higher ( P <0.0001) CRP, IL-6, and sCD40L than controls. Fourteen patients experienced a CV event. Cox regression analysis showed that only high sCD40L levels ( P =0.003) independently predicted cardiovascular risk. Conclusions— High levels of sCD40L may predict the risk of CV events in ALCS.

yearjournalcountryeditionlanguage
2005-01-01Stroke
https://doi.org/10.1161/01.str.0000154878.58398.14