6533b853fe1ef96bd12ac3d4
RESEARCH PRODUCT
Active immunization of homosexual men using a recombinant hepatitis B vaccine
R. ClemensR. VothGeorg HessS. RossolDarline Cheatham‐spethKarl-hermann Meyer Zum Büschenfeldesubject
AdultCD4-Positive T-LymphocytesMaleViral Hepatitis VaccinesHepatitis B virusHBsAgAdolescentmedicine.disease_causeActive immunizationVirusVirologyHIV Seropositivitymental disordersHumansMedicineHepatitis B AntibodiesHepatitis B virusVaccinesVaccines SyntheticHepatitis B Surface Antigensbiologybusiness.industryvirus diseasesHomosexualityMiddle AgedHepatitis Bbiology.organism_classificationmedicine.diseaseVirologyBlood Cell CountVaccinationInfectious DiseasesHepadnaviridaeImmunologybiology.proteinAntibodybusinesspsychological phenomena and processesdescription
Twenty homosexual men [13 anti-human immunodeficiency virus (HIV)-positive, seven anti-HIV negative] without HBsAg, anti-HBs, and anti-HBc were vaccinated with three 20 micrograms doses of a recombinant hepatitis B vaccine. All anti-HIV-positive homosexuals were nonresponders independent of the initial number of CD4-positive cells. Among seven anti-HIV-negative individuals, five responded. After three doses of the vaccine, CD4-positive cells fell in anti-HIV positive individuals by 22.4%. A similar fall in CD4-positive cells of an average 24.9% was noted in 17 matching, but nonvaccinated, anti-HIV-positive homosexuals. The study indicates that the efficacy of vaccination in anti-HIV-positive individuals is questionable. There is, however, no evidence that vaccination against hepatitis B might be harmful to anti-HIV-positive subjects.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-12-01 | Journal of Medical Virology |