ChemInform Abstract: Gold-Catalyzed Intramolecular Hydroamination of o-Alkynylbenzyl Carbamates: A Route to Chiral Fluorinated Isoindoline and Isoquinoline Derivatives.

6533b853fe1ef96bd12ac9bb

RESEARCH PRODUCT

ChemInform Abstract: Gold-Catalyzed Intramolecular Hydroamination of o-Alkynylbenzyl Carbamates: A Route to Chiral Fluorinated Isoindoline and Isoquinoline Derivatives.

Santos Fustero Silvia Catalan Miguel A. Maestro Pablo Barrio Ignacio Ibáñez

subject

chemistry.chemical_compound Cycloisomerization Nucleophile Chemistry Intramolecular force Sonogashira coupling General Medicine Hydroamination Isoindoline Isoquinoline Medicinal chemistry Catalysis

description

Title compounds are prepared in enantiomerically pure form by the diastereoselective addition of fluorinated nucleophiles to N-(tert-butanesulfinyl)imines (I) followed by a sequence of Sonogashira cross-coupling/gold(I)-catalyzed cycloisomerization of the corresponding carbamate.

year	journal	country	edition	language
2013-06-13	ChemInform

https://doi.org/10.1002/chin.201327140

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