Search results for "Isoindoline"

showing 8 items of 8 documents

Gold-Catalyzed Intramolecular Hydroamination of o-Alkynylbenzyl Carbamates: A Route to Chiral Fluorinated Isoindoline and Isoquinoline Derivatives

2013

Enantiomerically pure fluorinated isoindoline and dihydroisoquinoline scaffolds have been prepared through a diastereoselective addition of fluorinated nucleophiles to Ellman’s N-(tert-butanesulfinyl)imines followed by a sequence of Sonogashira cross-coupling/gold(I)-catalyzed cycloisomerization of the corresponding carbamate. A more favored 5-exo-dig mechanism was observed mainly due to an electronic effect of the fluorinated group.

Hydrocarbons FluorinatedMolecular StructureChemistryOrganic ChemistrySonogashira couplingStereoisomerismIsoindolineIsoindolesIsoquinolinesBiochemistryMedicinal chemistryCatalysischemistry.chemical_compoundCycloisomerizationNucleophileIntramolecular forceElectronic effectOrganic chemistryHydroaminationCarbamatesGoldPhysical and Theoretical ChemistryIsoquinolineAmines
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2-[(1-Methyl-1H-pyrrol-2-yl)carbonyl-meth-yl]isoindoline-1,3-dione.

2009

The asymmetric unit of the title compound, C15H12N2O3, contains two almost identical molecules forming an nearly C2-symmetric dimeric pattern. The dihedral angles between the pyrrole ring and the phthalimide unit are 82.95 (8) and 86.57 (8)° for the two molecules. Within such a dimer, the phthalimide units of the two molecules form a dihedral angle of 1.5 (5)°.

ChemistryDimerGeneral ChemistryMeth-IsoindolineDihedral angleCondensed Matter PhysicsBioinformaticsRing (chemistry)Medicinal chemistryOrganic Paperslcsh:ChemistryPhthalimidechemistry.chemical_compoundlcsh:QD1-999General Materials SciencePyrroleActa crystallographica. Section E, Structure reports online
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1,1,3,3-Tetraethyl-5-nitroisoindoline

2019

The title compound, C16H24N2O2, previously obtained as a yellow oil, exhibits a rather low melting point close to room temperature 297–298 K). In the molecule, the isoindoline ring system is approximately planar and coplanar to the nitro group, forming a dihedral angle of 5.63 (15)°. In the crystal, only weak N—H...O and C—H...π interactions are observed, linking molecules into chains parallel to the [101] direction.

crystal structurebiologyIsoindolineCrystal structureDihedral angle010402 general chemistry010403 inorganic & nuclear chemistryRing (chemistry)biology.organism_classificationstructure–property relationshiporganic synthesis01 natural sciences0104 chemical sciencesCrystalCrystallographychemistry.chemical_compoundchemistryNitrolcsh:QD901-999TetraOrganic synthesislcsh:CrystallographyIUCrData
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ChemInform Abstract: Gold-Catalyzed Intramolecular Hydroamination of o-Alkynylbenzyl Carbamates: A Route to Chiral Fluorinated Isoindoline and Isoqui…

2013

Title compounds are prepared in enantiomerically pure form by the diastereoselective addition of fluorinated nucleophiles to N-(tert-butanesulfinyl)imines (I) followed by a sequence of Sonogashira cross-coupling/gold(I)-catalyzed cycloisomerization of the corresponding carbamate.

chemistry.chemical_compoundCycloisomerizationNucleophileChemistryIntramolecular forceSonogashira couplingGeneral MedicineHydroaminationIsoindolineIsoquinolineMedicinal chemistryCatalysisChemInform
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Farinomalein derivatives from an unidentified endophytic fungus isolated from the mangrove plant Avicennia marina

2012

Five farinomalein derivatives including three new compounds, farinomaleins C–E (3–5), and one new isoindoline congener (6) were isolated from an unidentified endophytic fungus obtained from the inner tissues of healthy leaves of the mangrove plant Avicennia marina from Oman. The structures of the new compounds were unambiguously elucidated on the basis of their mass, as well as one and two dimensional NMR spectroscopic data.

Mangrove plantsbiologyChemistryOrganic ChemistryIsoindolineEndophytic fungusbiology.organism_classificationBiochemistryAvicenniachemistry.chemical_compoundCongenerAvicennia marinaDrug DiscoveryBotanyMangroveFarinomaleinTetrahedron Letters
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Pt(II) and Pd(II)-assisted coupling of nitriles and 1,3-diiminoisoindoline : Synthesis and luminescence properties of (1,3,5,7,9-pentaazanona-1,3,6,8…

2017

Treatment of trans-[PtCl2(NCR)2] 1 (R = Me (1a), Et (1b), o-ClC6H4 (1c), p-ClC6H4 (1d), p-(HCdouble bond; length as m-dashO)C6H4 (1e), p-O2NC6H4CH2 (1f)) with 1,3-diiminoisoindoline HNdouble bond; length as m-dashCC6H4C(NH)double bond; length as m-dashNH 2 gives access to the corresponding (1,3,5,7,9-pentaazanona-1,3,6,8-tetraenato)Pt(II) complexes [PtCl{NHdouble bond; length as m-dashC(R)Ndouble bond; length as m-dashC(C6H4)NCdouble bond; length as m-dashNC(R)double bond; length as m-dashNH}] 3a–f, in good yields (65–70%). The reaction of trans-[PdCl2(NCMe)2] 4a with 2 furnishes (1,3,5,7,9-pentaazanona-1,3,6,8-tetraenato)Pd(II) complex [PdCl{NHdouble bond; length as m-dashC(Me)Ndouble bond…

kemiaStereochemistryhiili1Solid-state010402 general chemistrychemistry01 natural sciencesMedicinal chemistrynitrogenInorganic Chemistrychemistry.chemical_compoundpentaazanonatetraene complexestyppiMaterials ChemistryluminescencenitrilesPhysical and Theoretical Chemistryta116Dichloromethanemetal-assisted additions010405 organic chemistryluminesenssicarbonCoupling (probability)0104 chemical scienceschemistryYield (chemistry)13-diiminoisoindolinePolystyreneAbsorption (chemistry)Luminescence3-diiminoisoindolinePolyhedron
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CCDC 750634: Experimental Crystal Structure Determination

2009

Related Article: J.Schlosser, D.Schollmeyer, S.Laufer, C.Peifer|2009|Acta Crystallogr.,Sect.E:Struct.Rep.Online|65|o2375|doi:10.1107/S1600536809034515

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters2-((1-Methyl-1H-pyrrol-2-yl)carbonylmethyl)isoindoline-13-dioneExperimental 3D Coordinates
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CCDC 1405500: Experimental Crystal Structure Determination

2016

Related Article: Mohamed Mehdi Rammah, Wafa Gati, Hasan Mtiraoui, Mohamed El Baker Rammah, Kabula Ciamala, Michael Knorr, Yoann Rousselin, Marek M. Kubicki|2016|Molecules|21|307|doi:10.3390/molecules21030307

Space GroupCrystallographyCrystal SystemCrystal Structureethyl 2-benzyl-3-oxo-1-((3-phenyl-12-oxazol-5-yl)methyl)isoindoline-1-carboxylateCell ParametersExperimental 3D Coordinates
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