6533b853fe1ef96bd12acb42

RESEARCH PRODUCT

Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia : a systematic review

Carlos Augusto Galvão BarbozaJadson Alexandre Da Silva LiraLélia Batista De SouzaRodrigo Porpino MafraEverton Freitas De MoraisRoseana De Almeida FreitasJuliana Campos Pinheiro

subject

OncologyEpithelial dysplasiamedicine.medical_specialtyEpithelial-Mesenchymal TransitionReviewCochrane LibraryInternal medicineBiomarkers TumorMedicineEpithelial–mesenchymal transitionStage (cooking)General DentistryMalignant phenotypeOral Medicine and Pathologybusiness.industryMechanism (biology)Prognosis:CIENCIAS MÉDICAS [UNESCO]Epitheliummedicine.anatomical_structureOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASImmunohistochemistrySurgerybusinessBiomarkers

description

Background Oral potentially malignant disorders (OPMDs) comprise a range of clinical-pathological alterations that are frequently characterized as architectural and cytological derangements upon histological analysis. Epithelial-mesenchymal transition (EMT) has been proposed as a critical mechanism for the acquisition of the malignant phenotype in neoplastic epithelial processes. This study aims to systematically review the current findings on the immunohistochemical expression of epithelial-mesenchymal transition markers in oral potentially malignant disorders and to evaluate their possible application as biomarkers associated with the progression of oral epithelial dysplasias. Material and Methods A systematic search was performed in the following databases: PubMed, EMBASE, Chinese BioMedical Literature Database, and Cochrane Library. Articles that evaluated the relationship between the expression of EMT markers and the degree of oral epithelial dysplasia were selected for the systematic review. The quality of each eligible study was evaluated by independent reviewers that used operationalized prognostic biomarker reporting guidelines (REMARK). Results Seventeen articles met all inclusion criteria and were selected. The EMT markers analyzed exhibited an important association with the prognosis of the cases evaluated. The results showed a progressive increase in the expression of nuclear transcription factors and markers of mesenchymal differentiation, as well as negative regulation of epithelial and cell adhesion markers, according to the stage of oral epithelial dysplasia. Conclusions The dysregulation of expression of important EMT components in oral dysplastic epithelium is a potential prognostic marker in OPMDs. Key words:Oral potentially malignant disorder, oral epithelial dysplasia, epithelial-mesenchymal transition, biomarker, prognosis.

yearjournalcountryeditionlanguage
2019-06-29
https://hdl.handle.net/10550/77105