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RESEARCH PRODUCT
Effects of High Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS) on Delay Discounting in Major Depressive Disorder: An Open-Label Uncontrolled Pilot Study
Magali NicolierMagali NicolierDjamila BennabiStéphane MouchabacGrégory TioJuliana Teti MayerEmmanuel Haffensubject
medicine.medical_specialty[SDV]Life Sciences [q-bio]medicine.medical_treatmentimpulsivityAudiologyImpulsivitybehavioral disciplines and activitiesArticlelcsh:RC321-57103 medical and health sciences0302 clinical medicinemental disordersmedicineTemporal discountinglcsh:Neurosciences. Biological psychiatry. Neuropsychiatrydelay discountingmajor depressive disorderbusiness.industryGeneral Neurosciencerepetitive transcranial magnetic stimulationhigh frequency repetitive transcranial magnetic stimulationCognitionmedicine.disease030227 psychiatry3. Good healthDorsolateral prefrontal cortexTranscranial magnetic stimulationmedicine.anatomical_structure[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthBrain stimulationMajor depressive disordermedicine.symptombusinessTreatment-resistant depression030217 neurology & neurosurgerydescription
Background: Delay discounting (DD) refers to the decrease of a present subjective value of a future reward as the delay of its delivery increases. Major depressive disorder (MDD), besides core emotional and physical symptoms, involves difficulties in reward processing. Depressed patients often display greater temporal discounting rates than healthy subjects. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique applied in several countries to adult patients with treatment resistant depression. Studies suggest that this technique can be used to modulate DD, but no trial has assessed its effects on depressed patients. Methods: In this open-label uncontrolled trial, 20 patients diagnosed with MDD and at least stage II treatment resistance criteria underwent 20 HF-rTMS sessions over the dorsolateral prefrontal cortex (dlPFC
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-09-01 | Brain Sciences |