Inhibition of inflammatory responses by epitaondiol and other marine natural products

6533b853fe1ef96bd12acc16

RESEARCH PRODUCT

Inhibition of inflammatory responses by epitaondiol and other marine natural products

María Luisa Ferrándiz Juana Rovirosa Aurelio San-martín Amalia Ubeda Blanca Gil María Carmen Terencio Maria-jesus Sanz Miguel Payá María José Alcaraz

subject

Blood Platelets Neutrophils medicine.drug_class Anti-Inflammatory Agents Cytochrome c Group Biology Leukotriene B4 Phospholipases A General Biochemistry Genetics and Molecular Biology Anti-inflammatory law.invention Mice chemistry.chemical_compound Phospholipase A2 Superoxides law medicine Animals Edema Humans Potency Ear External General Pharmacology Toxicology and Pharmaceutics Epitaondiol Calcimycin Inflammation Phospholipase A Terpenes Superoxide Anti-Inflammatory Agents Non-Steroidal Degranulation General Medicine Stimulation Chemical Thromboxane B2 Phospholipases A2 Biochemistry chemistry Recombinant DNA biology.protein Tetradecanoylphorbol Acetate Steroids Oxidation-Reduction Sesquiterpenes

description

The marine metabolites pacifenol, stypotriol triacetate and epitaondiol were tested for their effects on a number of inflammatory responses. Epitaondiol exhibited a potent topical anti-inflammatory activity related to inhibition of leukocyte accumulation. The other compounds showed a lower potency, similar to that of indomethacin. None of the compounds affected superoxide generation by human neutrophils but pacifenol effectively inhibited the degranulation response. This compound and epitaondiol decreased the release of eicosanoids with a higher potency on the cyclo-oxygenase pathway. Only epitaondiol inhibited human recombinant synovial phospholipase A2 activity in a concentration-dependent manner.

year	journal	country	edition	language
1995-06-01	Life Sciences

https://doi.org/10.1016/0024-3205(95)00260-d

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