6533b853fe1ef96bd12acd75

RESEARCH PRODUCT

Stir bar sorptive-dispersive microextraction mediated by magnetic nanoparticles-metal organic framework composite: Determination of N-nitrosamines in cosmetic products

Amparo SalvadorAlberto ChisvertPablo MirallesIris Van Gemert

subject

AnalyteNitrosaminesSorbentLiquid Phase MicroextractionCosmetics010402 general chemistryMass spectrometry01 natural sciencesBiochemistryChemistry Techniques AnalyticalAnalytical Chemistrychemistry.chemical_compoundLimit of DetectionTandem Mass SpectrometryLiquid chromatography–mass spectrometryMagnetite NanoparticlesMetal-Organic FrameworksDetection limitChromatography010401 analytical chemistryOrganic ChemistryGeneral MedicineRepeatability0104 chemical sciencesHexanechemistryMagnetic nanoparticlesHydrophobic and Hydrophilic InteractionsChromatography Liquid

description

Abstract A new analytical method based on the recently proposed stir bar sorptive-dispersive microextraction (SBSDME) technique has been developed to determine eight hazardous N-nitrosamines in cosmetic products. As previous step, a simple clean-up is carried out with hexane to remove those highly lipophilic compounds that disturb the SBSDME step. Subsequently, SBSDME is performed by using magnetic nanoparticles–metal organic framework composite, CoFe2O4/MIL-101(Fe), as sorbent to entrap the target analytes, which are later chemically desorbed and measured by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The experimental variables related to the SBSDME procedure were studied to achieve the highest analytical signal. Under the most favorable conditions, the proposed method was validated providing good linearity; enrichment factors up to 62 depending on the analyte; limits of detection from 3 to 13 µg kg−1; and good repeatability values (RSD

yearjournalcountryeditionlanguage
2019-06-25Journal of Chromatography A
https://doi.org/10.1016/j.chroma.2019.460465