6533b853fe1ef96bd12acd87

RESEARCH PRODUCT

CK-BB as indicator of prenatal brain-cell injury in fetuses with absent or reverse end-diastolic flow velocities of the umbilical arteries

P. BerleAndré Picard-maureauStefan UlrichE. Weiss

subject

HemodynamicsUmbilical cordUmbilical ArteriesAndrologyPregnancymedicine.arteryHumansMedicineCreatine KinaseBrain DiseasesFetusbiologybusiness.industryInfant NewbornObstetrics and GynecologyGestational ageUmbilical arteryBlood flowAnatomyFetal BloodIsoenzymesFetal Diseasesmedicine.anatomical_structureCord bloodPediatrics Perinatology and Child Healthbiology.proteinFemaleCreatine kinasebusinessBlood Flow Velocity

description

The purpose of this study is to determine the levels of brain type isoenzyme of creatine kinase (CK-BB) as a possible indicator of a pre-existing intrauterine brain-cell damage in cord blood sera of fetuses with preceding absent or reverse end-diastolic flow velocities of the umbilical arteries (AREDFV). CK-BB isoenzyme activities were determined in umbilical cord sera of 13 newborn infants with preceding AREDFV and in 14 fetuses with low end-diastolic flow velocities (LEDFV) of the umbilical arteries. 50 newborn infants with elective cesarean section and normal umbilical artery blood flow velocity waveforms were used as controls. Two-tailed Student's t-test and Fischer's exact test were used for statistical evaluation of the results. CK-BB isoenzyme activity did not depend on gestational age. Fetuses with AREDFV showed a significant increase in CK-BB values, whereas fetuses with LEDFV had CK-BB activities within the normal range of the controls. The elevated CK-BB values of the AREDFV group were not correlated with fetal acidosis at birth. Brain-cell injury with leakage of CK-BB isoenzyme might be present in fetuses with AREDFV even before (preterm) delivery.

yearjournalcountryeditionlanguage
1994-01-01jpme
https://doi.org/10.1515/jpme.1994.22.3.219