Role of Ocular Angiogenic Factors in the Development of Neovascular Age-Related Macular Degeneration

6533b853fe1ef96bd12acd9c

RESEARCH PRODUCT

Role of Ocular Angiogenic Factors in the Development of Neovascular Age-Related Macular Degeneration

Kristine Baumane Elīza Briede Angelika Krūmiņa

subject

0301 basic medicine pigment epithelium-derived factor medicine.medical_specialty Multidisciplinary vascular endothelial growth factor genetic structures General interest Science angiogenic factors Q biomarkers Macular degeneration medicine.disease eye diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Age related Ophthalmology 030221 ophthalmology & optometry medicine sense organs

description

Abstract Age-related macular degeneration (AMD) is a progressive degenerative eye disease. Neovascular age-related macular degeneration (nAMD) is the advanced form of AMD characterised by abnormal growth of newly formed blood vessels in chorioidea which typically involves fluid accumulation in the retina or retinal haemorrhage, retinal epithelial detachments, hard exudate or subretinal scars. The process of angiogenesis is controlled by ocular angiogenic factors, which have enabled the development of different treatment options aimed at these factors. This review aims to compile the available information about the most commonly identified ocular angiogenic factors, uncovering their role in the pathogenesis of nAMD and assessing their application possibilities as biomarkers of disease identification and treatment.

year	journal	country	edition	language
2020-06-01	Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

https://doi.org/10.2478/prolas-2020-0026

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