6533b853fe1ef96bd12acd9e
RESEARCH PRODUCT
Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins
José Luis RíosFlavio FranciniGuillermo Raúl SchinellaIsabel AndújarIsabel Andújarsubject
Enfermedad cardiovascularPharmaceutical SciencePharmacology01 natural sciencesAnalytical Chemistry//purl.org/becyt/ford/1 [https]Tratamiento médicoDPP-4Drug DiscoveryReceptorchemistry.chemical_classificationGIPGLUCAGON-LIKE PEPTIDE-1digestive oral and skin physiologyGlucagon-like peptide-1Diabetes mellitus tipo 2HomeopatíaINCRETINSMolecular MedicineCIENCIAS NATURALES Y EXACTAShormones hormone substitutes and hormone antagonistsendocrine systemOtras Ciencias BiológicasIncretinIncretinsCiencias BiológicasDiabetes mellitusDiabetes MellitusmedicineAnimalsHumansHypoglycemic Agents//purl.org/becyt/ford/1.6 [https]Dipeptidyl peptidase-4PharmacologyBiological ProductsPlants MedicinalGuar gum010405 organic chemistryOrganic ChemistryGLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDEmedicine.diseaseDIPEPTIDYL PEPTIDASE-40104 chemical sciences010404 medicinal & biomolecular chemistryEnzymeComplementary and alternative medicinechemistryGLP-1PhytotherapyHormonedescription
Incretins are metabolic hormones released after a meal that increase insulin secretion from pancreatic β-cells. The two main incretins are the intestinal peptides glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Both induce a decrease in glycemia, slow down the absorption of nutrients, and are inactivated by the enzyme dipeptidyl peptidase-4. Recently, incretin-based therapies have become a useful tool to treat diabetic patients, and different studies have focused on the identification of glucagon-like peptide-1 receptor agonists, including those of natural origin. This review focuses on the new findings of medicinal plants and natural products as possible active agents on the potentiation of incretin receptor signaling. Among these, soluble fiber from species of Plantago and guar gum show promising effects, iridoid derivatives are relevant activators of incretin receptors, and derivatives of cyanidin, especially diglycosylated ones, are an interesting source of dipeptidyl peptidase-4 inhibitors. Fil: Ríos, José Luis. Universidad de Valencia; España Fil: Andújar, Isabel. Universidad de Valencia; España. Universidad Europea de Valencia.; España Fil: Schinella, Guillermo Raúl. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina Fil: Francini, Flavio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; Argentina
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-04-01 |