Immunogenicity of a combination vaccine containing diphtheria toxoid, tetanus toxoid, three-component acellular pertussis, hepatitis B, inactivated polio virus, and Haemophilus influenzae type b when given concomitantly with 13-valent pneumococcal conjugate vaccine.

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RESEARCH PRODUCT

Immunogenicity of a combination vaccine containing diphtheria toxoid, tetanus toxoid, three-component acellular pertussis, hepatitis B, inactivated polio virus, and Haemophilus influenzae type b when given concomitantly with 13-valent pneumococcal conjugate vaccine.

Gimenez-sanchez Francisco Kieninger Dorothee M Kueper Kathrin Federico Martinon-torres Bernaola Enrique Diez-domingo Javier Steul Kathrin Juergens Christine Gurtman Alejandra Giardina Peter Liang John Z Gruber William C Emini Emilio A Scott Daniel A Zimmer Johannes

subject

Male medicine.disease_cause Antibodies Viral Diphtheria-Tetanus-acellular Pertussis Vaccines complex mixtures Pneumococcal conjugate vaccine Drug Administration Schedule Pneumococcal Vaccines Antigen Double-Blind Method Germany medicine Humans Hepatitis B Vaccines Vaccines Combined Diphtheria-Tetanus-Pertussis Vaccine Haemophilus Vaccines Vaccines Conjugate General Veterinary General Immunology and Microbiology biology Tetanus business.industry Diphtheria Poliovirus Immunogenicity Public Health Environmental and Occupational Health Infant Hepatitis B medicine.disease Virology Antibodies Bacterial Poliovirus Vaccine Inactivated Infectious Diseases Treatment Outcome Spain biology.protein Molecular Medicine Female Antibody business medicine.drug

description

Two randomized trials of 13-valent pneumococcal conjugate vaccine (PCV13) relative to PCV7 evaluated the immune responses of coadministered antigens comprising Infanrix(®) hexa/Infanrix(®)-IPV+Hib (diphtheria, tetanus, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Haemophilus influenzae type b). After the 3-dose infant series, immunogenic noninferiority was demonstrated for all concomitantly administered antigens between the PCV13 and PCV7 groups. All antigens elicited good booster responses after the toddler dose except pertussis toxoid; however, 99.6% subjects achieved pertussis toxoid protective antibody level ≥5EU/mL in both groups. These results support the concomitant administration of PCV13 and Infanrix hexa/Infanrix-IPV+Hib as part of routine immunization schedules.

year	journal	country	edition	language
2011-01-22	Vaccine

10.1016/j.vaccine.2011.06.026 https://pubmed.ncbi.nlm.nih.gov/21704105