6533b853fe1ef96bd12ace08
RESEARCH PRODUCT
Prognostic indicators for squamous cell carcinoma of the oral cavity: a clinicopathologic correlation.
Jack L. GluckmanKeith M. WilsonJ. S. McdonaldLouis G. PortugalPeter J. StambrookHans J. WelkoborskyZlatko P. PavelicPeter S. GartsideDavid L. StewardWolf J. MannLyon L. GleichPaul D. RighiPaul W. Biddingersubject
MalePathologymedicine.medical_specialtyCellular differentiationMitosisTongueCarcinomamedicineHumansNeoplasm InvasivenessGrading (tumors)Mouth FloorNeoplasm StagingRetrospective StudiesCell NucleusParaffin Embeddingbusiness.industryMicrocirculationRetrospective cohort studyCell DifferentiationMiddle Agedmedicine.diseaseGenes p53PrognosisTongue NeoplasmsGene Expression Regulation NeoplasticLymphatic systemmedicine.anatomical_structureTreatment OutcomeOtorhinolaryngologyEpidermoid carcinomaLymphatic MetastasisCarcinoma Squamous CellFemaleMouth NeoplasmsLymph NodesNeoplasm Recurrence LocalbusinessInfiltration (medical)Follow-Up StudiesForecastingdescription
Fifty-three patients with T1 squamous cell cancer of the floor of mouth and ventral surface of the tongue with a known clinical outcome were retrospectively analyzed and arbitrarily divided into "aggressive" and "nonaggressive" groups based on their clinical behavior. Various host and tumor factors were then evaluated in an attempt to determine whether the tumor behavior could have been predicted. The paraffin-embedded tumor specimens were evaluated for tumor differentiation, tumor thickness and tumor invasion, microvessel density, and p53 expression. In addition, a composite morphologic grading score was obtained by combining cell differentiation, nuclear polymorphism, mitosis activity, depth of infiltration, type of infiltration, and lymphatic infiltration. No single technique appeared capable of identifying "aggressive" behavior, although possibly an evaluation of composite factors might show promise in the future.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-09-01 | The Laryngoscope |