Factor analyses of multidimensional symptoms in a large group of patients with major depressive disorder, bipolar disorder, schizoaffective disorder and schizophrenia

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RESEARCH PRODUCT

Factor analyses of multidimensional symptoms in a large group of patients with major depressive disorder, bipolar disorder, schizoaffective disorder and schizophrenia

Michael Franz Verena Enneking Simon Schmitt Elena Fischer Axel Krug Tina Meller Udo Dannlowski Cynthia Kraus Frederike Stein Matthias M. Müller Gunnar Lemmer Tilo Kircher Birgit Köhnlein Lutz Lenhard Igor Nenadic Dominik Grotegerd Achim Bäcker Katharina Brosch Harumi Murata Susanne Meinert Arne Nagels Katharina Förster Katharina Koch

subject

Bipolar Disorder Schizoaffective disorder 03 medical and health sciences 0302 clinical medicine Humans Medicine Bipolar disorder Medical diagnosis Biological Psychiatry Psychiatric Status Rating Scales Depressive Disorder Major business.industry medicine.disease Confirmatory factor analysis 030227 psychiatry Psychiatry and Mental health Psychotic Disorders Schizophrenia Schizophrenia Major depressive disorder Factor Analysis Statistical business Large group 030217 neurology & neurosurgery Psychopathology Clinical psychology

description

Abstract Background There is an ongoing discussion about which neurobiological correlates or symptoms separate the major psychoses (i.e. Major Depressive Disorder MDD, Bipolar Disorder BD, and Schizophrenia SZ). Psychopathological factor analyses within one of these disorders have resulted in models including one to five factors. Factor analyses across the major psychoses using a comprehensive set of psychopathological scales in the same patients are lacking. It is further unclear, whether hierarchical or unitarian models better summarize phenomena. Method Patients (n = 1182) who met DSM-IV criteria for MDD, BD, SZ or schizoaffective disorder were assessed with the SANS, SAPS, HAMA, HAM-D, and YMRS. The sample was split into two and analyzed using explorative and confirmatory factor analyses to extract psychopathological factors independent of diagnosis. Results In the exploratory analysis of sample 1 (n = 593) we found 5 factors. The confirmatory analysis using sample 2 (n = 589) confirmed the 5-factor model (χ2 = 1287.842, df = 571, p Conclusion This is the first study delineating psychopathological factors in a large group of patients across the spectrum of affective and psychotic disorders. In future neurobiological studies, we should consider transdiagnostic syndromes besides the traditional diagnoses.

year	journal	country	edition	language
2020-04-01	Schizophrenia Research

https://doi.org/10.1016/j.schres.2020.03.011