6533b853fe1ef96bd12ace27
RESEARCH PRODUCT
Enantioselective synthesis of pyrazolone α-aminonitrile derivatives via an organocatalytic Strecker reaction
Suruchi MahajanKari RissanenKristina DeckersPankaj ChauhanUğur KayaDieter Enderssubject
Strecker amino acid synthesisPyrazolone010402 general chemistry01 natural sciencesCatalysischemistry.chemical_compoundNucleophileMaterials ChemistrymedicineOrganic chemistryenantioselective synthesisTrimethylsilyl cyanideta116010405 organic chemistryMetals and AlloysSquaramideEnantioselective synthesisGeneral Chemistry0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialschemistryStrecker reactionElectrophileCeramics and CompositesEnantiomermedicine.drugdescription
A new organocatalytic enantioselective Strecker reaction of pyrazolone-derived ketimine electrophiles has been developed. Using pseudo-enantiomeric squaramide catalysts the nucleophilic 1,2-addition of trimethylsilyl cyanide to the ketimines efficiently provides a direct entry to both enantiomers of pyrazolone α- aminonitrile derivatives at will in good yields and high enantioselectivities for a wide variety of substrates. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-06-07 |