Liposomes from α,ω-dipolar amphiphiles with a polymerizable diyne moiety in the hydrophobic chain

6533b853fe1ef96bd12ad3ab

RESEARCH PRODUCT

Liposomes from α,ω-dipolar amphiphiles with a polymerizable diyne moiety in the hydrophobic chain

subject

chemistry.chemical_compound Liposome Monomer Aqueous solution chemistry Polymerization Vesicle Monolayer Amphiphile technology industry and agriculture Moiety Photochemistry

description

Symmetric polymerizable α,ω-dipolar C22-diacetylenes were prepared by oxidative coupling of 10-undecynoic acid and 10-undecynol, respectively, by means of copper II salts in ethanolic solution. 10,12-Docosadiyne-1,22-diphosphate (3)—by reaction of 10,12-docosadiyne-1,22-diol (2) with POCl3—was polymerized in aqueous solution using UV irradiation to form deep blue, thermochromic solutions. By consonication of 3 with cholesterol, monolayer vesicles were formed. This was proven by encapsulation of 6-carboxyfluorescein. These monomeric vesicles were polymerized by UV light to yield stable, deep blue polymeric vesicle suspensions.

year	journal	country	edition	language
1982-06-01	Journal of Polymer Science: Polymer Chemistry Edition

https://doi.org/10.1002/pol.1982.170200622

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