6533b853fe1ef96bd12ad3e0

RESEARCH PRODUCT

Chiral cyclohexane based fluorescent chemosensors for enantiomeric discrimination of aspartate

Pablo GaviñaAna M. CosteroSalvador GilMihály KállayKrisztina PálManuel ColeraMiklós KubinyiMiklós Kubinyi

subject

inorganic chemicalsCircular dichroismCyclohexaneChemistryStereochemistryorganic chemicalsOrganic ChemistryAbsolute configurationBiochemistryFluorescenceIonCrystallographychemistry.chemical_compoundDrug Discoveryhealth occupationspolycyclic compoundsheterocyclic compoundsEnantiomerStoichiometry

description

Some new chiral cyclohexyl based fluorescent anion receptors have been synthesized and their absolute configuration has been determined by using circular dichroism (CD). Complexation experiments have been carried out with several dicarboxylates, and stoichiometries and complexation constants for the corresponding complexes have been determined. The chiral discrimination ability of these ligands for chiral dicarboxylates has been studied and the best results have been obtained with TMA aspartate.

yearjournalcountryeditionlanguage
2008-03-01Tetrahedron
https://doi.org/10.1016/j.tet.2008.01.085