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RESEARCH PRODUCT
Analysis of13C NMR substituent chemical shifts in some (aryl)(2-nitrobenzo [b]thiophen-3-yl)amines: A new class of compounds with analgesic, anti-exudative and anti-inflammatory activities showing low mutagenicity
Domenico SpinelliM. C. SarvaLiliana LamartinaFrancesco Guerrerasubject
Stereochemistrymedicine.drug_classChemistryChemical shiftArylAnalgesicSubstituentGeneral ChemistryCarbon-13 NMRResonance (chemistry)Anti-inflammatorychemistry.chemical_compoundParameter analysismedicineGeneral Materials Sciencedescription
The 13C NMR chemical shift values of (aryl)(2-nitrobenzo[b]thiophen-3-yl)amines were measured in DMSO-d6 solutions, suggesting the occurrence of an alternate charge polarization at C-3, C-2, C-3a, C-7a, C-4 and C-5. A dual substituent parameter analysis of the experimental data indicates a large or a low resonance contribution for aryl para or meta substituents, respectively, while the inductive component remains constant throughout.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-11-01 | Magnetic Resonance in Chemistry |