6533b853fe1ef96bd12ad699

RESEARCH PRODUCT

Standard additions-dilution method for absolute quantification in voltammetry of microparticles. Application for determining psychoactive 1,4-benzodiazepine and antidepressants drugs as adulterants in phytotherapeutic formulations

María Teresa Doménech-carbóAntonio Doménech-carbóMariele MartiniLeandro Machado De CarvalhoCarine VianaMiguel F. Silva

subject

BupropionBromazepamBenzodiazepineFlurazepamChemistrymedicine.drug_classClinical BiochemistryPharmaceutical ScienceLorazepamElectrochemical TechniquesPharmacologyAntidepressive AgentsClonazepamAnalytical ChemistryBenzodiazepinesAlprazolamStandard additionDrug DiscoverymedicinePlant PreparationsDrug ContaminationBrazilSpectroscopymedicine.drug

description

A standard additions-dilution solid-state electrochemical method for the determination of psychoactive 1,4-benzodiazepine and antidepressants drugs used as adulterants in commercial slimming herbal formulations is described and compared with conventional standard addition method. The proposed method, based on the voltammetry of microparticles approach, permits quantify, via standard additions methodology, 1,4-benzodiazepine and antidepressants drugs in phytotherapeutic formulations with no need of sample dissolution using dilution with a reference electroactive compound. The method was used to measure 1,4-benzobenzodiazepines (clonazepam, flurazepam, alprazolam, midazolam, bromazepam, chlordiazepoxide, lorazepam and diazepam) and antidepressants (bupropion, sertraline, paroxetine and fluoxetine) in slimming formulations that have been commercialized in Brazil.

yearjournalcountryeditionlanguage
2013-01-22Journal of Pharmaceutical and Biomedical Analysis
https://doi.org/10.1016/j.jpba.2013.03.005