6533b853fe1ef96bd12ad6f5
RESEARCH PRODUCT
Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa.
Nicole J. De VoogdLaurent MeijerMarie-lise Bourguet-kondrackiEmilie DurieuMai Hoang LinhWerner E. G. M�llerArlette LongeonSherif S. EbadaAbdel Nasser B. SingabPeter Prokschsubject
Marine spongesbiologyMolecular StructureOrganic ChemistryPlant Sciencebiology.organism_classificationBiochemistryAnalytical ChemistryPoriferaMiceAlkaloidsStylissa massaBiochemistryGenusIndonesiaCell Line TumorStylissa flabelliformisAnimalsPyrrolesDispacamide EProtein Kinase Inhibitorsdescription
Chemical investigation of methanolic extracts of the two Indonesian marine sponges Stylissa massa and Stylissa flabelliformis yielded 25 bromopyrrole alkaloids including 2 new metabolites. The structures of all isolated compounds were unambiguously elucidated based on extensive 1D and 2D NMR, LR-MS and HR-MS analyses. All isolated compounds were assayed for their antiproliferative and protein kinase inhibitory activities. Several of the tested compounds revealed selective activity(ies) which suggested preliminary SARs of the isolated bromopyrrole alkaloids.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-01-01 | Natural product research |