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RESEARCH PRODUCT
Inflammatory Murine Skin Responses to UV-B Light Are Partially Dependent on Endothelin-1 and Mast Cells
Marcus MaurerMarcus MaurerVerena LammelMartin MetzBernhard F. Gibbssubject
Endothelin A Receptor AntagonistsUltraviolet RaysCell DegranulationRatónDermatitisMice TransgenicInflammationBiologyPharmacologyCell DegranulationPathology and Forensic MedicineMicemedicineAnimalsMast CellsReceptorInflammationEndothelin-1integumentary systemDegranulationDose-Response Relationship RadiationReceptor Endothelin AMast cellEndothelin 1medicine.anatomical_structureImmunologymedicine.symptomEndothelin receptorRegular Articlesdescription
Endothelin (ET-1) has been shown to crucially contribute to UV-induced skin responses such as tanning. To test whether ET-1 is also involved in early cutaneous reactions to UV, we assessed ET-1 skin levels in UV-irradiated mice. In correlation with the levels of UV-induced skin inflammation, ET-1 concentrations increased substantially and continually. Moreover, blocking of ET-1 receptors (ET A ) resulted in significantly decreased cutaneous inflammation following UV irradiation. When we assessed skin responses to ET-1 injections, we observed prominent mast cell degranulation and mast cell-dependent inflammation. Since mast cells also critically contributed to UV-induced inflammation, we determined the ET-1-dependent inflammatory response to UV in the absence and presence of these cells. Interestingly, ET A blockade did not decrease UV-induced inflammation in mast cell-deficient mice, unless these mice had been adoptively transferred with mast cells before irradiation. This indicates that skin inflammation due to UV irradiation is caused in part by ET-1 acting on skin mast cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-09-01 | The American Journal of Pathology |