6533b853fe1ef96bd12ad7c9

RESEARCH PRODUCT

From an epoxide monomer toolkit to functional PEG copolymers with adjustable LCST behavior.

Boris ObermeierFrederik R. WurmHolger FreyChristine Mangold

subject

Ethylene OxideMaterials scienceHot TemperaturePolymers and PlasticsPolymersAllyl glycidyl etherpolyethersEpoxideLower critical solution temperaturePolymerizationPolyethylene Glycolschemistry.chemical_compoundPolymer chemistrycopolymersMaterials ChemistryCopolymerPoly(Ethylene Glycol) CopolymersSide-ChainsAqueous-SolutionEthylene oxideComonomerstimuli-sensitiveOrganic ChemistryPegchemistryPolymerizationGlycidolLcstEthylene glycolHydrophobic and Hydrophilic Interactions

description

The lower critical solution temperature (LCST) behavior of novel poly(ethylene glycol) (PEG)-based copolymers bearing multiple functional groups, obtained by anionic ring-opening (co)polymerization (AROP), has been investigated. Variable comonomer ratios of ethylene oxide (EO) and the corresponding oxiranes isopropylidene glyceryl glycidyl ether (IGG), ethoxyl vinyl glycidyl ether (EVGE), allyl glycidyl ether (AGE), or N,N-dibenzyl amino glycidyl (DBAG), particularly designed to implement functional groups at the PEG backbone, were found to influence the LCST behavior. Sharp transitions from translucent to opaque solutions, comparable to other well-established stimuli-responsive polymers, were observed at temperatures ranging from 9 to 82 degrees C. The influence of the side group hydrophobicity could be quantified by the comparison of the different copolymer systems observed.

yearjournalcountryeditionlanguage
2011-10-04Macromolecular rapid communications
10.1002/marc.201100489https://pubmed.ncbi.nlm.nih.gov/21971715